Creamy Cajun Salmon Pasta

5 from 13 votes

Cajun Salmon Pasta: smoky, bold, and flaky salmon top a bed of creamy tomato-infused fettuccine alfredo for a satisfying, delicious, and quick 30-minute dinner everyone will love!

Prep Time10

Cook Time20

Total Time30

Course: Main Course

Cuisine: American

Servings: servings

Calories: 467kcal

Author: Megan Byrd, RD

Cost: $19.74 or $2.47/serving

Equipment

1 large skillet

Ingredients

16 oz dry fettuccine noodles
1 ½ lbs salmon fillets
2 tbsp avocado oil divided
3 tbsp homemade cajun seasoning divided
4 cloves garlic minced
1 cup whole milk
4 oz cream cheese cut into cubes
1 cup freshly grated parmesan cheese
¼ cup shredded mozzarella cheese
15 oz canned fire roasted tomatoes
1 cup chopped fresh spinach

Instructions

Preheat the oven to 425°. Cook the pasta according to the package instructions. Drain the pasta and set it aside.
Place the salmon filets skin side down on a lined or greased baking sheet. Drizzle with 1 tbsp oil and sprinkle with 1 tbsp cajun seasoning. Bake the salmon in the preheated oven for 16-20 minutes (depending on the thickness of the filets), until cooked through to 145°. Set aside.
Meanwhile, heat the remaining 1 tablespoon of avocado oil on medium heat. Add the garlic and saute for about 1 minute.
Add the milk and cream cheese. Break the cream cheese up as it melts, and whisk/stir until everything is combined with no lumps.
Add the parmesan, mozzarella, and remaining 2 tbsp cajun seasoning and stir constantly until the cheese has melted.
Stir in the fire-roasted tomatoes, then the fresh spinach.
Add the drained noodles to the skillet and toss to coat with the cajun sauce. Remove the skins from the salmon, then top the pasta with the salmon. Serve!

Notes

Recipe Tips:

Homemade Cajun Seasoning: Make a large batch of homemade cajun seasoning and store leftovers for the next time you make this recipe. If you don't have the ingredients for the homemade seasoning, you can also use a pre-made cajun blend, though the sodium levels of the final recipe will likely differ.
Pasta Substitutes: Almost any other long shape of pasta can substitute for fettuccine: linguine, pappardelle, spaghetti, bucatini, and more.
Salmon Substitutes: Deveined and peeled raw shrimp can work in place of the salmon. Bake the shrimp for only 8-10 minutes or until cooked through and no longer pink.

Storage Directions: Leftover salmon cajun pasta keeps covered in an airtight container in the refrigerator for 2-3 days. It does not freeze well. Reheat the leftovers on medium heat in the microwave until warmed through.

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